A four-amino-acid peptide modeled on a pineal-gland extract, studied for melatonin rhythm, sleep quality and the biology of cellular aging. Taken in short courses.
Subcutaneous injection
Price
Coming soon
Price announced at launch. Get notified and be first in line.
Chapter 04 · Renew
Sleep and healthy aging
What it's studied for
Epitalon has a long research history in longevity science, mostly from one group of researchers in Russia. It's promising, early and not yet independently confirmed at scale.
Studies in older animals and small groups of older adults have looked at how Epitalon affects nighttime melatonin, which tends to flatten with age.
Lab studies on human cells found Epitalon could switch on telomerase, the enzyme that maintains telomeres, the protective caps on your chromosomes.
Long-running animal studies have looked at markers of aging and lifespan, which is why Epitalon is a staple of longevity protocols.
Epitalon is typically taken for a short course and then paused for months. Your physician sets the course and how often to repeat it.
The science
Your pineal gland, a small gland deep in the brain, sets your body's night-time rhythm by releasing melatonin. Epitalon is modeled on peptides from that gland.
Epitalon (Ala-Glu-Asp-Gly) is a synthetic version of the active peptide in epithalamin, an extract of the pineal gland studied for decades.
Research suggests it may help restore a more youthful pattern of melatonin release, the hormone that signals night to every cell in your body.
In lab studies, Epitalon activated telomerase in human cells. Whether that translates into meaningful changes in people is still an open question.
We summarize the published research as it stands, including what isn't known yet.
Evidence: Preclinical + early human
What's been studied
What we don't know yet
Research summaries are for education, not a promise of results. Epitalon is a compounded medication and is not FDA-approved. Your physician will talk you through what to realistically expect.
How it's used
Your physician sets your dose, schedule and how long you take it. Here's what a typical protocol looks like.
Subcutaneous injection
A small subcutaneous injection under the skin of the belly or thigh, with a fine insulin needle, often in the evening.
Typical protocol
Commonly a short daily course of about two to three weeks, repeated once or twice a year. Your physician sets your course.
In your package
Not a complete list. Your physician reviews your full health history.
Stack it with
Treatments people commonly add alongside Epitalon. Your physician decides what fits your health and goals.
Your care
A physician in your corner, start to finish.
How it works
Tell us about your health, your goals and anything you've tried before. It takes a few minutes, on any device.
A physician reviews your history, medications and goals, checks for anything that would make a peptide a poor fit, and may message you with questions.
If peptide therapy is appropriate, your physician recommends a protocol (dose, schedule and length) and you see your price before you pay.
A licensed US pharmacy prepares your prescription and ships it free, with everything you need and clear instructions.
Message your care team anytime. Your physician can adjust, pause or stop your protocol based on how you're doing.
Questions
Straight answers about Epitalon.
BPC-157 injections and TB-500 are $149 a month and MOTS-c is $199 a month; pricing for the other peptides will be announced at launch. Peptides aren't available to order yet: join the waitlist and we'll email you when your visit opens. Shipping is free and there's no insurance needed.
Epitalon protocols are typically short courses of a few weeks, repeated once or twice a year, rather than an everyday medication. Your physician sets your course length and when to repeat it.
No. Epitalon is a compounded medication: it's prepared for you, from a prescription, by a licensed US pharmacy. Compounded medications are not FDA-approved, which means the FDA hasn't reviewed them for safety or effectiveness. That's why a licensed physician reviews your health history before anything is prescribed.
We can't promise that. Lab studies found Epitalon activated telomerase in human cells, but there's no strong evidence yet that it lengthens telomeres or extends lifespan in people. We think it's worth being honest about that.
Epitalon is generally reported to be well tolerated. Possible side effects include injection-site redness or irritation, drowsiness, headache and vivid dreams. Your physician will check in during your course.
Tell your physician about any melatonin, sleep aid or sedative you take. Your physician will decide whether Epitalon fits alongside them.
Websites selling peptides "for research use only" aren't pharmacies. There's no prescription, no physician and no assurance of what's actually in the vial. Your peptide is prescribed by a licensed physician after a medical review and prepared by a licensed US compounding pharmacy.
Important safety information
Not for use if you are pregnant or breastfeeding, have active cancer or a history of cancer, or are under 18. Tell your physician about any sleep medication.
Epitalon (epithalon) is a synthetic tetrapeptide. Human research is limited to small studies, mostly from one research group, and long-term safety in people has not been established.
Possible side effects may include: injection-site redness, irritation or bruising, drowsiness, headache, and vivid dreams.
Contraindications: Epitalon may not be appropriate if you are pregnant, planning a pregnancy or breastfeeding; have an active cancer or a history of cancer (because of its studied effect on telomerase); are under 18; or have a known allergy to any component. Tell your physician if you take melatonin, sleep aids or sedatives.
This therapy should only be used under the supervision of a licensed healthcare provider. Tell your physician about every medication and supplement you take.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Compounded medications are not FDA-approved.
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