PeptidesPerform
Coming soon · Metabolic energyMitochondrial-derived peptide
Exercise in a peptide.
A peptide made by your own mitochondria, studied for how your body uses fuel, responds to insulin and handles exercise. Natural levels tend to fall with age.
Subcutaneous injection
Price
$199 /month
Coming soon. Get notified and be first in line when it launches.
Chapter 02 · Perform
Metabolic energy
What it's studied for
MOTS-c was discovered in 2015 and has quickly become one of the most interesting peptides in metabolism research. Most of the evidence so far comes from animal studies.
Animal studies have looked at how MOTS-c helps cells switch between burning sugar and fat, a trait that tends to fade with age and inactivity.
In mice fed high-fat diets, MOTS-c has been studied for its effect on insulin resistance and weight gain.
Research in older mice found improvements in physical performance, which is why MOTS-c is sometimes called an exercise mimetic.
Circulating MOTS-c appears to decline with age and rise with exercise, making it a focus of longevity research.
The science
Most of your DNA lives in the nucleus, but your mitochondria carry a tiny genome of their own. MOTS-c is one of the few peptides it encodes.
MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA. It's one way your cells' power plants communicate with the rest of the body.
Research suggests MOTS-c activates AMPK, the same energy-sensing pathway that exercise switches on, shifting cells toward using glucose and fat more efficiently.
When cells are under metabolic stress, MOTS-c can move into the nucleus and influence genes involved in stress resistance and metabolism.
We summarize the published research as it stands, including what isn't known yet.
Evidence: Preclinical + early human
What's been studied
What we don't know yet
Research summaries are for education, not a promise of results. MOTS-c is a compounded medication and is not FDA-approved. Your physician will talk you through what to realistically expect.
How it's used
Your physician sets your dose, schedule and how long you take it. Here's what a typical protocol looks like.
Subcutaneous injection
A small subcutaneous injection under the skin of the belly or thigh, with a fine insulin needle.
Typical protocol
Protocols commonly use a few injections a week for a set course, often timed around training days. Your physician sets your dose and schedule.
In your package
Not a complete list. Your physician reviews your full health history.
Stack it with
Treatments people commonly add alongside MOTS-c. Your physician decides what fits your health and goals.
Your care
A physician in your corner, start to finish.
How it works
Tell us about your health, your goals and anything you've tried before. It takes a few minutes, on any device.
A physician reviews your history, medications and goals, checks for anything that would make a peptide a poor fit, and may message you with questions.
If peptide therapy is appropriate, your physician recommends a protocol (dose, schedule and length) and you see your price before you pay.
A licensed US pharmacy prepares your prescription and ships it free, with everything you need and clear instructions.
Message your care team anytime. Your physician can adjust, pause or stop your protocol based on how you're doing.
Questions
Straight answers about MOTS-c.
BPC-157 injections and TB-500 are $149 a month and MOTS-c is $199 a month; pricing for the other peptides will be announced at launch. Peptides aren't available to order yet: join the waitlist and we'll email you when your visit opens. Shipping is free and there's no insurance needed.
No. MOTS-c is studied for metabolic flexibility, insulin sensitivity and exercise capacity, mostly in animals. It isn't a substitute for a GLP-1 medication, nutrition or exercise, and we don't promise weight loss with it.
No. MOTS-c is a compounded medication: it's prepared for you, from a prescription, by a licensed US pharmacy. Compounded medications are not FDA-approved, which means the FDA hasn't reviewed them for safety or effectiveness. That's why a licensed physician reviews your health history before anything is prescribed.
Your physician sets your schedule. Many protocols use a few injections a week, and some time them around training days. Your kit includes step-by-step instructions.
Reported side effects are usually mild: injection-site redness or soreness, temporary tiredness, and occasional changes in heart rate or a warm feeling. Tell your physician if you take diabetes medication, because MOTS-c is studied for its effects on blood sugar.
Some people use both, and your physician will decide whether that's appropriate for you. Tell us about every medication you take, especially anything that lowers blood sugar.
MOTS-c is prohibited under the World Anti-Doping Agency (WADA) code, in and out of competition. If you're subject to drug testing in your sport, don't use it, and tell your physician during your visit.
Websites selling peptides "for research use only" aren't pharmacies. There's no prescription, no physician and no assurance of what's actually in the vial. Your peptide is prescribed by a licensed physician after a medical review and prepared by a licensed US compounding pharmacy.
Important safety information
Not for use if you are pregnant or breastfeeding, have active cancer, or are under 18. Use caution with blood-sugar-lowering medications. Prohibited in WADA-tested sport.
MOTS-c is a synthetic version of a 16-amino-acid mitochondrial-derived peptide. Research on it is mostly in animals, and long-term safety in people has not been established.
Possible side effects may include: injection-site redness, soreness or bruising, temporary fatigue, a warm or flushed feeling, and changes in heart rate.
Blood sugar: MOTS-c is studied for its effects on glucose metabolism. If you take insulin, a GLP-1 or other diabetes medication, your physician needs to know, and may advise monitoring.
Contraindications: MOTS-c may not be appropriate if you are pregnant, planning a pregnancy or breastfeeding; have an active cancer; are under 18; or have a known allergy to any component.
Athletes: MOTS-c is not approved for human therapeutic use and is prohibited under the World Anti-Doping Agency (WADA) code.
This therapy should only be used under the supervision of a licensed healthcare provider. Tell your physician about every medication and supplement you take.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Compounded medications are not FDA-approved.
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