A three-amino-acid fragment of alpha-MSH, a hormone your body uses to quiet inflammation, studied for gut and skin comfort. A needle-free oral tablet.
Oral tablet (LPT)
Price
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Chapter 05 · Restore
Gut and skin calm
What it's studied for
KPV is the smallest peptide we offer: just three amino acids. The research is promising but early, and almost all of it is in lab and animal models.
In animal models of gut inflammation, KPV taken by mouth was studied for how it calms inflammatory signaling in the lining of the intestine.
Lab and animal studies have looked at KPV's effect on inflammatory signals in skin cells and on wound healing.
KPV is small enough to be absorbed in the gut, so it's prescribed as an oral tablet. No syringes, no mixing.
KPV comes from alpha-MSH, the hormone behind tanning, but this fragment doesn't act on the pigment receptor, so it isn't expected to change skin color.
The science
Alpha-MSH is a hormone your body makes to keep inflammation in check. KPV is the three-amino-acid tail of that hormone, and it seems to carry much of the calming effect.
KPV is lysine-proline-valine, the last three amino acids of alpha-MSH (alpha-melanocyte-stimulating hormone).
Research suggests KPV is carried into intestinal cells by a transporter called PepT1, which is more active when the gut lining is inflamed.
Inside cells, KPV appears to dampen NF-κB, a central switch that turns on inflammatory signals.
We summarize the published research as it stands, including what isn't known yet.
Evidence: Preclinical
What's been studied
What we don't know yet
Research summaries are for education, not a promise of results. KPV is a compounded medication and is not FDA-approved. Your physician will talk you through what to realistically expect.
How it's used
Your physician sets your dose, schedule and how long you take it. Here's what a typical protocol looks like.
Oral tablet (LPT)
An oral tablet, taken by mouth. No needles, no mixing.
Typical protocol
Commonly taken daily for a set course. Your physician sets your dose and how long to take it.
In your package
Not a complete list. Your physician reviews your full health history.
Stack it with
Treatments people commonly add alongside KPV. Your physician decides what fits your health and goals.
Your care
A physician in your corner, start to finish.
How it works
Tell us about your health, your goals and anything you've tried before. It takes a few minutes, on any device.
A physician reviews your history, medications and goals, checks for anything that would make a peptide a poor fit, and may message you with questions.
If peptide therapy is appropriate, your physician recommends a protocol (dose, schedule and length) and you see your price before you pay.
A licensed US pharmacy prepares your prescription and ships it free, with everything you need and clear instructions.
Message your care team anytime. Your physician can adjust, pause or stop your protocol based on how you're doing.
Questions
Straight answers about KPV.
BPC-157 injections and TB-500 are $149 a month and MOTS-c is $199 a month; pricing for the other peptides will be announced at launch. Peptides aren't available to order yet: join the waitlist and we'll email you when your visit opens. Shipping is free and there's no insurance needed.
No. KPV is studied for calming inflammatory signaling, but it isn't a treatment for inflammatory bowel disease or any other condition. If you have a diagnosed gut condition, keep working with your gastroenterologist and tell your physician in your visit.
No. KPV is a compounded medication: it's prepared for you, from a prescription, by a licensed US pharmacy. Compounded medications are not FDA-approved, which means the FDA hasn't reviewed them for safety or effectiveness. That's why a licensed physician reviews your health history before anything is prescribed.
KPV is an oral tablet. Your physician sets your dose and how long to take it, and your package includes dosing and storage instructions.
KPV is generally reported to be well tolerated. Possible side effects include mild stomach upset or headache. Because human data are limited, your physician will check in and adjust or stop your protocol if needed.
It isn't expected to. KPV comes from alpha-MSH, the hormone involved in tanning, but research suggests this small fragment doesn't act on the pigment receptor.
Websites selling peptides "for research use only" aren't pharmacies. There's no prescription, no physician and no assurance of what's actually in the vial. Your peptide is prescribed by a licensed physician after a medical review and prepared by a licensed US compounding pharmacy.
Important safety information
Not for use if you are pregnant or breastfeeding or under 18. Not a treatment for IBD or any other condition.
KPV is a synthetic tripeptide (lysine-proline-valine). Research on it is preclinical, and safety in people has not been established in controlled trials.
Possible side effects may include: mild stomach upset, nausea, and headache.
Contraindications: KPV may not be appropriate if you are pregnant, planning a pregnancy or breastfeeding; are under 18; or have a known allergy to any component. KPV is not a treatment for inflammatory bowel disease or any other condition. Seek medical care for bleeding, unexplained weight loss, fever or severe abdominal pain.
This therapy should only be used under the supervision of a licensed healthcare provider. Tell your physician about every medication and supplement you take.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Compounded medications are not FDA-approved.
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