A seven-amino-acid peptide developed from a fragment of ACTH, studied for focus, memory and BDNF, the brain's own growth factor. A needle-free nasal spray.
Nasal spray
Price
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Chapter 03 · Focus
Clear, calm concentration
What it's studied for
Semax was developed in Russia in the 1980s and has been prescribed there for decades. It isn't FDA-approved, and much of the research is in Russian-language and animal studies.
Semax has been studied for attention and mental performance, especially under fatigue or stress.
Animal studies found Semax increases BDNF, a protein that supports the growth and maintenance of brain cells and the connections between them.
Researchers have studied Semax for memory and learning in animal models and small human studies.
Semax is absorbed through the lining of the nose, so it's prescribed as a nasal spray. No needles, no mixing.
The science
Semax starts with a short piece of ACTH, a hormone involved in your stress response, and adds a stabilizing tail. Unlike full ACTH, it is designed to act on the brain rather than on your adrenal glands.
Semax copies a small piece of ACTH, plus three amino acids that keep it from breaking down too quickly. It doesn't trigger cortisol release the way full ACTH does.
In animal studies, Semax raised levels of BDNF and its receptor in the hippocampus, the brain region most tied to learning and memory.
Sprayed into the nose, Semax is absorbed through the nasal lining, which is why it doesn't need an injection.
We summarize the published research as it stands, including what isn't known yet.
Evidence: Preclinical + early human
What's been studied
What we don't know yet
Research summaries are for education, not a promise of results. Semax is a compounded medication and is not FDA-approved. Your physician will talk you through what to realistically expect.
How it's used
Your physician sets your dose, schedule and how long you take it. Here's what a typical protocol looks like.
Nasal spray
A metered nasal spray. A small number of sprays in each nostril, usually earlier in the day.
Typical protocol
Commonly used daily for a course of a few weeks, then a break. Your physician sets your dose and course.
In your package
Not a complete list. Your physician reviews your full health history.
Stack it with
Treatments people commonly add alongside Semax. Your physician decides what fits your health and goals.
Your care
A physician in your corner, start to finish.
How it works
Tell us about your health, your goals and anything you've tried before. It takes a few minutes, on any device.
A physician reviews your history, medications and goals, checks for anything that would make a peptide a poor fit, and may message you with questions.
If peptide therapy is appropriate, your physician recommends a protocol (dose, schedule and length) and you see your price before you pay.
A licensed US pharmacy prepares your prescription and ships it free, with everything you need and clear instructions.
Message your care team anytime. Your physician can adjust, pause or stop your protocol based on how you're doing.
Questions
Straight answers about Semax.
BPC-157 injections and TB-500 are $149 a month and MOTS-c is $199 a month; pricing for the other peptides will be announced at launch. Peptides aren't available to order yet: join the waitlist and we'll email you when your visit opens. Shipping is free and there's no insurance needed.
No. Semax isn't a stimulant like caffeine or ADHD medication. It's studied for its effects on BDNF and on dopamine and serotonin signaling. Some people do find it energizing, which is why it's usually used earlier in the day.
No. Semax is a compounded medication: it's prepared for you, from a prescription, by a licensed US pharmacy. Compounded medications are not FDA-approved, which means the FDA hasn't reviewed them for safety or effectiveness. That's why a licensed physician reviews your health history before anything is prescribed.
Your physician sets your dose, usually a small number of sprays per nostril, typically in the morning. Your package includes step-by-step instructions and how to store the spray.
Possible side effects include nasal irritation, headache, and occasionally restlessness, irritability or trouble sleeping if used late in the day. Your physician will check in and adjust or stop your protocol if needed.
Tell your physician about every medication you take, especially stimulants, antidepressants or anything for anxiety. Your physician will decide whether Semax is appropriate alongside them.
Websites selling peptides "for research use only" aren't pharmacies. There's no prescription, no physician and no assurance of what's actually in the vial. Your peptide is prescribed by a licensed physician after a medical review and prepared by a licensed US compounding pharmacy.
Important safety information
Not for use if you are pregnant or breastfeeding, have a seizure disorder or a severe psychiatric condition, or are under 18.
Semax is a synthetic heptapeptide based on a fragment of adrenocorticotropic hormone (ACTH). It is not FDA-approved, and much of the human research was conducted in Russia in people with medical conditions. Long-term safety in healthy adults has not been established.
Possible side effects may include: nasal irritation or dryness, headache, restlessness, irritability, and trouble sleeping (especially if used late in the day).
Contraindications: Semax may not be appropriate if you are pregnant, planning a pregnancy or breastfeeding; have a seizure disorder; have a severe anxiety disorder, psychosis or another serious psychiatric condition; are under 18; or have a known allergy to any component. Tell your physician about stimulants, antidepressants and anxiety medications.
This therapy should only be used under the supervision of a licensed healthcare provider. Tell your physician about every medication and supplement you take.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Compounded medications are not FDA-approved.
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